Scientists restore vision in mice, achieve 170-fold gene editing boost

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Scientists at MIT and Harvard found a better way to fix genetic mistakes. They have designed tiny, virus-like particles to carry prime editors into mouse cells with a high success rate, effectively correcting a genetic disorder.
Prime editing is a versatile gene-editing technique capable of correcting disease-causing genetic mutations.
By tweaking these engineered virus-like particles (eVLPs) – they improved the editing process by 170 times in human cells. In tests on mice with genetic eye problems, they corrected the mistakes and partially restored their vision.
Promising treatment for genetic disorders
Importantly, when they used the same method to edit genes in the mouse brain, there were no unintended changes. This breakthrough suggests prime editing could be a promising treatment for genetic disorders in living animals.


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